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Importantly, these studies controlled for important covariates such as age, BMI, smoking, chronotype, and timing of sample collection, reinforcing the robustness of this association 177,178,179,180,181,182

As a result, peripheral tissues such as blood and cerebrospinal fluid (CSF) from patients are now being used to study the underlying molecular mechanisms of psychiatric disease

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Conducted experimental studies Study 2 Material Male albino rats weighing between 280-320 g

3,5,22,24 AATD typically presents as panlobular basal emphysema in individuals aged younger than 45 years

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