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The concern stems from its activation of the VEGFR2 pathway and FAK-paxillin signaling, which drive angiogenesis and are dysregulated in 50% of human cancers (ovarian cancer, melanoma, and colon adenocarcinoma)

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3 A widely used non-radioactive alternative is the C breath test , in which a stable-isotope-labeled substrate (often octanoate or spirulina) is metabolized after it passes into the small intestine, so the rate of labeled CO appearance in the breath reports on emptying