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Cell Survival Under Stress

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Targeting early degenerative changes, such as synaptic loss, axonal transport disruption, mitochondrial compromise, and glial dysfunction, may prove more effective than attempting to reverse advanced neuronal death [27, 28]

It kills any kind of cells regardless of the expression of c-Met protein, and the cytotoxicity of tivantinib is related to inhibit microtubule assembly ( Cabozantinib is a novel small-molecule multi-target tyrosine kinase inhibitor of c-Met, VEGFRs, RET, KIT, and AXL (Yakes et al., 2011)

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We recommend injections be administered once weekly for 4 weeks, followed by once a month