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[1] Rybelsus contains semaglutide, a GLP-1 receptor agonist that mimics the action of naturally occurring incretin hormones
Data were acquired using an MS3-based TMT method using the following scan parameters: scan sequence began with an MS1 master scan (Orbitrap analysis, resolution 120,000, 4001700 m/z, RF lens 60%, automatic gain control [AGC] target 2E5, maximum injection time 50 ms, centroid mode) with dynamic exclusion enabled (repeat count 1, duration 15 s)
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Then 5 days later, both eyes were injected with vehicle or Eru (n = 7 for AAV2-Scr+vehicle, n = 8 for AAV2-Scr+Eru, n = 7 for AAV2-shTMEM19+vehicle, n = 8 for AAv2-shTMEM19+Eru), Two-sided multiple unpaired t-test with Benjamini-Krieger-Yekutieli FDR correction
Chen W, Hu F, Gao Q, Zheng C, Bai Q, Liu J, et al