Growing evidence points to ferroptosis (cell death caused by iron and lipids builds up as a by-product of this dehydration activity) as a reason for degeneration of chondrocytes in OA
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10.1016/j.bmcl.2017.07.013 Summary Keywords docking, MD simulations, pharmacophore, acetylcholinesterase, machine learning Citation Hayek-Orduz Y, Acevedo-Castro DA, Saldarriaga Escobar JS, Ortiz-Domnguez BE, Villegas-Torres MF, Caicedo PA, Barrera-Ocampo , Cortes N, Osorio EH and Gonzlez Barrios AF (2025) dyphAI dynamic pharmacophore modeling with AI: a tool for efficient screening of new acetylcholinesterase inhibitors
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It is posited to function similarly to Growth Hormone Releasing Peptides (GHRPs) and to apparently emulate the natural hunger hormone, ghrelin, particularly its potential to stimulate the release of hGH from pituitary cells
