As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5
Among all DAMs, the most significant alterations were observed in the levels of amino acid metabolites
Cell Host Microbe (2012) 11:2907
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Figure 3 Imbalances in T cell populations play significant roles in various diseases Alterations in T cell populations are observed in hyperuricemia and its related complications
