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doi: 10.3177/jnsv.51.426

Most were skin-related symptoms, but anaphylaxis is possible with IV NAC.[ref] Some people also report gastrointestinal side effects with NAC

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10.1093/jn/130.8.2073S 276 SchausR

As mentioned above, GSH is synthesized only in the cytoplasmic matrix, but it is also found in intracellular organelles, including the mitochondria, nucleus, and endoplasmic reticulum

Research has also linked low glutathione to increased risk of chronic conditions including diabetes, hypertension, and certain liver diseases