In many parts of the northwest, kinnikinnick, or bearberry ( Arctostaphylos uva ursi ) was the main smoke plant used by indigenous peoples, smoked with tobacco (when available), on its own, or mixed with a suite of other indigenous plants (20)
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Therefore, nicotine exposure during this critical period can lead to profound and rapid neuroadaptations in the brains reward pathways, specifically by influencing the dopamine and nicotinic acetylcholine receptors (nAChRs), increasing the susceptibility to addiction and decreasing the ability to control cravings 22
