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For instance, the novel triterpenoid methyl CDDO derivative (CDDO-Me) potently induced cytotoxicity in imatinib-resistant myeloid leukemia cells, accompanied by a rapid and selective depletion of mGSH resulting in increased generation of ROS and mitochondrial dysfunction (Samudio et al., 2005, 2008)

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[12] [13] BPC-157 has been widely used both by athletes and among the general public, mainly for recovery from injury or stimulating healing in chronic conditions, [14] [11] [15] [16] but there is as yet only very limited human trial data on efficacy and only a few preliminary safety studies

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