One significant limitation of GHK-Cu is its short in vivo half-life of approximately 30 minutes in plasma, combined with the instability of the metal-peptide complex due to copper high reactivity
Inhibiting glutamine pathway, including downregulating glutamine transporter ASCT2 [84] or inhibit glutaminase by CB-839 [85] can deplete intracellular GSH, but such effect of CB-839 was only observed in cancer cell lines expressing xCT supplied with high cystine in the culture [86]
M., Schlegel A
Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
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