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Zhang Z, Tang M, Liu W, Song Y, Gao M, Ni P, et al

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NAD + depletion elevates the methylation of BDNF promoter, triggering the dissociation of the DNA methylation-sensitive nuclear factor CCCTC-binding factor (CTCF) and cohesin from the BDNF locus

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However, a clear correlation between metal accumulation and the production of these compounds has not been established yet

Journal of Pharmacological Sciences, 93(2), 188196