Pausing is the standard recommendation
Cancers 15 , 3104 (2023)
3 The risk factors for methotrexate AEs include higher doses (3.5 g/m 2 ), rapid infusions, preexisting kidney impairment, older age (aged 50 years), and the concurrent use of medications that are nephrotoxic or that impair methotrexate clearance (eg, proton pump inhibitors, aminoglycosides, nonsteroidal anti-inflammatory drugs, penicillin and penicillin derivatives, amphotericin, probenecid)
Because the concentration is the same as the 10 mg with 2 mL example, a 2.5 mg dose is still 0.5 mL, or 50 U-100 units
1517 TPE is gaining ground for its potential to reduce oxidative stress, inflammation, senescent cells, and improve immune function
This means enlarged pores may shrink and dry patches diminish