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Tumor-specific E2F-1 gene overexpression from the human telomerase reverse transcriptase (HTERT) promoter enables targeted apoptosis in colon cancer in-vivo

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As mentioned above, despite the theoretical possibility that GH-RH agonists could stimulate prostate cell proliferation through GH/IGF-1 signaling, in vivo studies have paradoxically shown inhibitory effects on tumor growth due to receptor downregulation