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In some embodiments, the otic formulation or composition comprises about 0.02% by weight of the carbomer

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GHK-Cu peptide is a copper-binding peptide complex supplied for laboratory research in metallopeptide interactions and binding studies

GHK-Cu GHK-Cu is a copper-binding tripeptide studied in controlled laboratory environments for its role in cellular signaling, metal-ion interaction pathways, and extracellular matrix research models

Consistent with this, the ablation of CTR in AP neurons of mice blunted the anorectic effects of sCT (10 g/kg, equivalent to 3 nmol/kg) 44 and the ablation of CTR in NTS neurons in mice abrogated the long-term suppression of food intake upon sCT administration