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(39407841) Some case studies describe patients whose acidosis failed to respond to withdrawal of acetaminophen, but subsequently improved following the administration of acetylcysteine

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Therefore, GLS1 inhibitors (especially CB-839) have been described to restrain tumor cells proliferation, and also, due to a higher availability of interstitial glutamine, support the antitumor effects of CD8 + T cells, increasing their infiltration and reducing Tregs [203, 204]

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However, emerging evidence highlights the existence of a dynamic oral-gut axis, wherein oral microbes and their metabolites can translocate to the gastrointestinal tract, reshape gut microbial ecology, and impact host immunity and metabolism