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None on the second dose
Mechanistic gaps: The exact molecular pathways in human adipocytes remain under investigation
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In contrast, cells with lower senescence burden may have less FOXO4p53 dependence, or may buffer p53 relocalization through other regulators, which might explain the limited apoptosis in younger cultures compared to aged cell cultures
Mitochondrial Biogenesis MOTS-c and Slu-pp-332 are investigated for their roles in activating AMPK and PGC-1 signaling, respectively, leading to enhanced mitochondrial biogenesis and improved cellular energy production
