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A 2021 peer-reviewed review of NNMT in obesity and type 2 diabetes states explicitly that 'clinical trials targeting NNMT have not been reported' meaning every quantitative efficacy figure available for this compound comes from mice, and there is currently zero published human efficacy data

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Additionally, the oral bioavailability observed in animal models makes the compound attractive for potential clinical development

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Pabla also explains that there can be complications from an intramuscular shot

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