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10.1007/s00441-019-03016-8 23 HangaiM.YoshimuraN.HiroiK.MandaiM.HondaY

In animal ulcer models, it preserves mucosal integrity and reduces lesion size by modulating inflammatory pathways

Rotating sites systematically allows any irritation to resolve before returning to a previously used location

Research in animal models shows activity at approximately 0.5mcg/kg, though human protocols typically use standardized doses in the 1-3mg range regardless of body weight