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In the PIPD and MRgFUS datasets, motor symptoms were evaluated in the on-medication state using the MDS-UPDRS-III

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IGF-1 derivatives have played important roles in research studies on cell proliferation, cell division, and cell-to-cell communication

It binds to neuroligins and actin and regulates actin polymerization, growth cone motility, dendritic spine morphology, and synaptic transmission [283]

Vukojevic et al., Neural Regeneration Research, 2022)