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CoQ10 exists in three redox states: (1) ubiquinone as in oxidized state

The heterogeneous population of FM with genetic polymorphism and various neurotransmitters expression explains that why it is hard to predict correlations of various neurobiological reflections such as BDNF with clinical parameters in FM

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The survival rate of mice was observed by day 20

Zahavi I, Shaffer EA, Gall DG 1985 Total parenteral nutrition associated cholestasis: acute studies in infant and adult rabbits

[16] Although cyanocobalamin lacks a defined upper-toxicity threshold due to its water solubility and renal elimination, exceptionally high cumulative doses have been temporally associated with acneiform eruptions, altered potassium homeostasis, and theoretical thrombotic risk, emphasizing the importance of evidence-based dosing