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The mechanisms of ferroptosis were summarized into three interrelated aspects: iron metabolism, lipid peroxide metabolism, as well as glutathione and amino acid metabolism

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HMGB1 is a ubiquitously expressed nuclear protein engaged in the progression of nucleosome stabilization and DNA binding

Still, most of the BBB alterations described in toxin models mirror those found in post-mortem brain tissues, supporting the scenario that neuroinflammation impairs the BBB in PD