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As a corollary, in response to oxidant stress, G6PD-deficient hepatocytes exhibit transcriptomic network perturbations in redox pathways and immune response pathways (98)

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The latter results have encouraged the clinical evaluation of HGF (VM-202) gene transfer in human trials for neuropathic diabetic pain (NCT01475786) with the encouraging outcome of a 3-month pain relief period (Kessler et al., 2015)