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NMDAR antagonist MK-801 aggravates D1R-induced dyskinesias, while effectively reduces D2R-induced dyskinesias, the degree of which is of the same magnitude as the reduction of L-DOPA-induced dyskinesias ( There is an increase in the therapeutic index and locomotor improvement of L-DOPA with adenosine A2AR antagonists, like istradefylline (132) and tozadenant (133), which function also as a biomarker to monitor PD (134)
How it works in the body: Protection: The liposome acts as a vehicle, carrying the GSH safely through the digestive tract
Yao et al., 2006
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Acknowledgments We gratefully acknowledge Laboratori Farmaceutici Krymi (Rome, Italy) for their technical assistance and for kindly providing GSH-C4 and all clinical study medical devices as a gift
Another crucial factor is the usage rate
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