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Agmatine co-transmission in addiction Given reports of Glu/Agm co-transmission, and Agms dual roles as an extracellular antagonist of NMDA receptors (Figure 2) and an intracellular antagonist of NOS, it is reasonable to hypothesize that Agm may interact with the NMDA-NOS axis involved in addiction-driven learning experienced during withdrawal (Uzbay, 2012)