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PMID: 34057733

(February 2016)

These alterations collectively impair Nrf2-driven antioxidant and anti-inflammatory responses, resulting in diminished expression of downstream protective enzymes such as HO-1 and GSH ( BL has been shown to promote nuclear translocation of Nrf2, thereby upregulating HO-1 and enhancing the production of key antioxidant enzymes, including GSH, superoxide dismutase (SOD), and NAD(P)H quinone oxidoreductase 1 (NQO1) ( 2 O 2 exposure, compared with controls (Zhao et al., 2024)

Several indicators suggest the need for dose adjustment

Structural insights into omega-class glutathione transferases: a snapshot of enzyme reduction and identification of a non-catalytic ligandin site

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