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Its levels also decline with age.

This action increases the accumulation of FLC in cells and improves the antifungal efficacy of FLC

Studies of quadriceps muscle crush injuries demonstrate faster restoration of myotendinous junctions and reduced fibrosis at injury sites, preserving contractile function

Therefore, the p62-Keap1-NRF2 axis forms a feedback loop that positively regulates the cytoprotective effects of NRF2

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Developed by researchers in Australia, AOD-9604 was initially investigated as a potential anti-obesity drug due to its ability to stimulate lipolysis (fat breakdown) and inhibit lipogenesis (fat accumulation)