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They may also use modalities such as ice or heat to reduce inflammation and pain

R.HoldenH.et al (2005)

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Gastrointestinal motility modulation by stress is associated with reduced smooth muscle contraction through specific transient receptor potential channel

Under those conditions p53 is phosphorylated by ATM on Ser15, which blocks its MDM2-mediated degradation(Rodier et al., 2009)