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In addition to providing colonic epithelial cells with an energy substrate to sustain barrier function, butyrate also promotes Treg cell development via HDAC inhibitionmediated histone H3K27 acetylation at the Foxp3 gene locus (193195)

And the cherry on top

Ridha-Salman H, Al-Zubaidy AA, Abbas AH, Hassan DM, Malik SA (2025) The alleviative effects of canagliflozin on imiquimod-induced mouse model of psoriasis-like inflammation

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The control of ROS levels in cells is crucial for cellular homeostasis, as Moderate ROS levels in cells can serve as signaling molecules, but excessive ROS production can lead to damage to DNA, proteins, and lipids [2]