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This accumulation is accompanied by downregulation of glutathione peroxidase 4 (GPX4), upregulation of acyl-CoA synthetase long-chain family member 4 (ACSL4), and elevated lipid peroxidationhallmarks of ferroptotic cell death (Taylor et al., 2008)

-Ketoglutarate may contribute to the restoration of ovarian reserve and improve pregnancy rates in a CTX-induced POI rat model, potentially by inhibiting Caspase-3 activity (Li T

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