The manufacturer (EMD Serono) voluntarily discontinued Geref in 2008 for commercial reasons, not due to safety concerns
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While cysteine readily oxidizes to form the disulfide cystine, cells contain less cystine than cysteine in the cytosol because the ubiquitous reducing agent, glutathione (which contains cysteine), effectively reverses the formation of cystine by a non-enzymatic reduction reaction
PMID: 25216859