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Even so, elevated medium- and long-chain acylcarnitines have been documented in metabolic conditions involving impaired mitochondrial -oxidation, including medium-chain acyl-CoA dehydrogenase (MCAD) deficiency and other fatty acid oxidation defects, and have also been reported in cellular models of MMA [57, 58]

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[10] In humans , the expression of the enzymes involved in the pathway varies significantly between tissues

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J., Albusta, A