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Here, we have used a DIA mass spectrometry approach to compare a range of artemisinin resistant (Cam3.II R539T , Cam3.II C580Y and MRA1240) and sensitive parasites (Cam3.II REV and MRA1239) and for the first time also performed comparative proteomics analysis in 3-6 hpi ring-stage parasites, which is the stage at which artemisinin resistant parasites display differential survival relative to sensitive parasites (Supp data sheet 1)

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The compounds tested included dermorphin, [D-Arg]dermorphin, and a series of truncated [D-Arg]dermorphin fragments, namely [D-Arg]dermorphin(16), (15), (14), (13), and (12)

doi:10.1016/j.nbd.2012.09.015 3

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