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Second, proline substitutions at positions 25, 28, and 29 reduce the tendency to form beta-sheet structures that lead to aggregation

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We emphasize its combined effect on hippocampal neurons, which are known to be particularly vulnerable (Iwasaki et al., 2003), counteracting both early and delayed neural damage and achieving full functional recovery (based on the Morris water maze test, inclined beamwalking test, and lateral push test)