ALA
During the seeding stage in amyloid precursor protein (APP)/presenilin-21 (APP/PS1-21) animal models, the inhibition of ApoE4 with antisense oligonucleotides (ASOs) results in the formation of larger A plaques with reduced plaque-associated neuritic dystrophy (Ulrich et al., 2018)
Treatment typically begins at 2.5 mg once weekly for four weeks, serving as an initial tolerability dose rather than a therapeutic maintenance dose
Maximum results usually occur after 4-6 months of regular application
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