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Additionally, hormonal changes associated with menopause and menstruation may influence vitamin B12 absorption and metabolism, potentially contributing to vitamin B12 deficiency

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Measure whether daily maternal administration of vitamin B 12 from early pregnancy until 6 months postpartum improves development as measured by the Ages and Stages Questionnaire, Third Edition (ASQ-3), at 6 and 12 months of age

The compound's selectivity profile minimizes concerns about off-target effects, but investigators should consider potential interactions with other NAD+-modulating interventions or compounds that affect methylation metabolism

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