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The research strategy for these compounds is fundamentally different because their pharmacokinetics are different

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GHK-Cu provides the broader repair signal, supports collagen cross-linking, and helps maintain the skin barrier that retinol can disrupt

The difference after eight weeks was noticeable

If it goes the estrogen route, androstenedione is converted (using CYP19A1) first to estrone (E1), which is then converted (using 17-HSD) into estradiol.[ref] Here is a flow chart to give you a better idea of the conversion of cholesterol into estrogen, including the genes that are involved

But slowly, steadily, they're shrinking