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Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases

Front Oncol (2018) 8:411(411)

[DOI] [PubMed] [Google Scholar] 78.Sato K., Kameda M., Yasuhara T., Agari T., Baba T., Wang F., Shinko A., Wakamori T., Toyoshima A., Takeuchi H., et al

observed that the weaning-induced expansion of respiratory pathogens coincided with alterations in the expression of immune-related genes in blood leukocytes, suggesting that weaning-triggered endocrine shifts further compromised systemic immunological surveillance 106

The European Food Safety Authority (EFSA) has established an acceptable daily intake (ADI) of 3 mg/kg body weight (~210 mg/day for adults) as a conservative threshold (243)