We recently found that targeting BET proteins induces glutamate dehydrogenase 1 (GDH1)-dependent glutamine metabolic remodeling in liver cancer, where glutamine-derived -KG through GDH1 maintains cancer cell survival when glycolysis is compromised 23 , but the underlying mechanisms are not fully understood
Consult with a specialist to determine which method aligns best with your skin tone and lifestyle.
Liposomal glutathione is safe for long-term use when taken within the recommended dosage
PMC5467583
Acknowledgements This work was supported by the National Natural Science Foundation of China (81902422, 82403008), the China Postdoctoral Science Foundation (2024M762749), the Natural Science Foundation of Jiangsu Province (BK20231245, BK20250559), the program of Jiangsu Traditional Chinese Medicine Science and Technology Development (No.MS2024140), the key program of Jiangsu Provincial Health Commission (K2025009), Social Development Program of Yangzhou Science and Technology Bureau (No.YZ2025094), Yangzhou City Basic Research Program (Joint Special Project) - Health and Wellness Category (2024-2-08, 2025-2-08, and 2025-3-15), Natural Science Foundation of Minhang District (2025MHZ052)
Appl Microbiol Biotechnol 37:141146 Allocati N, Masulli M, Di Ilio C, Federici L (2018) Glutathione transferases: substrates, inhibitors and pro-drugs in cancer and neurodegenerative diseases
