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Previous study reported that although Nrf2 deficiency may reduce trabecular bone mass, compensatory bone remodeling or individual differences could lead to higher trabecular bone in some KO mice 53 , which also highlighted the functional diversity of Nrf2

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Finally, N-acetylation of this conjugate by the enzyme N-acetylase yields S-substituted-N-acetyl cysteine products called as mercapturic acids