Studies involving acoustic and chemical insults show that growth factors represent a compelling class of otoprotective compounds (Yagi et al., The HGF mimetic Dihexa is a synthetically derived Angiotensin IV analog that is blood-brain barrier permeable, stable, and orally bioavailable (McCoy et al., in vitro and in vivo , making a strong case for a small molecule activator of HGF/c-Met to confer a neuroprotective benefit (Zhang et al., The experimental value of zebrafish as an animal model for in vivo drug discovery has grown rapidly due to their ease of assessment, large clutch size, and ability to recapitulate human disease conditions (MacRae and Peterson, in vivo , demonstrating that otoprotective drug discovery in zebrafish translates to mammalian systems (Owens et al., In this study, we demonstrate that Dihexa protects lateral line hair cells from aminoglycoside ototoxicity
Individual ingredients have documented metabolic roles, but the combined injectable formulation lacks rigorous clinical trial evidence for dramatic body composition changes
They can weigh its benefits against the risks, with help from doctors
Ipamorelin appears to ease that brake during a short window
It is converted by the body into Adenosylcobalamin and Methylcobalamin so they can be absorbed
European Journal of Endocrinology , 139(5), 552-561
