FOXO4, one of the members of this family, interacts with the p53 protein to help senescent cells avoid apoptosis
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Support can be especially relevant when appetite is reduced, sleep is disrupted, or inflammation is persistent, because those states can make cellular maintenance more expensive
This process may be inhibited in the presence of FOXO4-DRI peptide, allowing p53 to bind with DNA and thereby help the cell cycle to continue to death
Traditionally, in vitro liver studies have mainly relied upon two-dimensional (2D) cell culture models, by using primary hepatocytes or immortalized cell lines such as HepG2 and HepaRG cells
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