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5.1.2 Enhancement of gut and bloodbrain barrier integrity Recent studies have shown that a vicious cycle of inflammation and oxidative stress is created at the renal level by the influx of uremic toxins and urea into the gastrointestinal lumen via the enterohepatic cycle, which exerts a selective pressure that encourages the excessive growth of bacterial species that produce urease, uricase, indole, and p-cresol-forming enzymes with a reduction in SCFAs-producing species (Vaziri et al., 2013

doi: 10.1242/dev.148296 60 RenFWangD-BLiTChenY-HLiY

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Interestingly, peritumoral capillary endothelial cells expressed genes associated with semi-professional antigen presentation, including HLA , but not CD80 and CD86 , and with scavenging activity, such as MARCO (19)

[ 1 ] Despite ongoing interest, DSIP remains an investigational compound