We erred on the side of lower passive absorption for children and decided not to recommend doses less frequently than once per day for children up to 3 years of age
10.3390/brainsci10090621 155
Preclinical studies document significant brain concentrations after systemic (including oral) administration, with behavioral improvements in hippocampal-dependent tasks confirming functionally relevant CNS penetration (PMID: 23055539)
Chang J 1 , Leong RW 2 , Wasinger VC3, Ip M4, Yang M4, Phan TG5
These effects (i.e., rapidly reestablished reorganized blood flow) attenuated/eliminated the lesions in the brain (intracerebral and intraventricular hemorrhage), heart (congestion, myocardial infarction, severe arrhythmias), lung (hemorrhage), and congestion and lesions in the liver, kidney, and gastrointestinal tract [54]
Bioavailability is the primary difference