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Neither has been tested in humans, and both carry significant unknowns -- Dihexa with its retracted publication and oncological pathway concerns, PE-22-28 with its untested cognitive effects and potential seizure susceptibility

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However, similar to -oxidation in the cytochromes, the peroxisomes generate ROS as they oxidize fatty acids, and likewise, the peroxisomes may induce oxidative stress and promote disease progression [83]