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In some embodiments, degradation of a therapeutic agent is reduced by the use of an appropriate of a buffer as described herein

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Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6

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Ultimately, the choice of protocol is up to the lead researcher