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In macrophages, the activation of mGluR5 elevates the level of the nuclear receptor peroxisome proliferator-activated receptor (PPAR) g and promotes a shift from M1 to M2 phenotype, leading to reduced IFN- production [180]

Warrick E, Duval C, Nouveau S, et al

doi:10.1371/journal.pone.0157389 Patibandla S, Heaton J, Kyaw H

M., & Kubow, S

For nonsevere spreading infections that can be addressed within 24 hours, penicillin monotherapy is recommended [3]

Mutations in PDI and ERp57 were also described in ALS patients, but are thought to be more of a risk factor than directly causative of neurodegeneration (Woehlbier et al., 2016)