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Additional diagnostic approaches include measuring bilirubin-UGT activity in the liver, which is typically low in GS patients, but does not always correlate with serum levels

Careful dose titration is essential, starting with the lowest available dose (2.5 mg weekly) for initiation only, with increases every 4 weeks as tolerated to reach therapeutic doses per FDA labeling

Vitamin B12 is water-soluble, meaning your body will typically eliminate any excess through urine

This article is a review and did not involve human participants, human data, human tissue, or animal experiments

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Ten out of the 19 fragment hits contained an amide or sulfonamide group that formed a hydrogen bond with either R131 or Q127 (Fig