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Principal coordinate analysis (PCoA) based on BrayCurtis inter-sample distance (PERMANOVA R 2 = 0.0413, p -value = 0.001) and unweighted UniFrac intersample distance (PERMANOVA, R 2 = 0.0454, p-value = 0.001) matrices showed clear separation between healthy and OSCC samples ( Figure 1C

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E-cigarettes, on the other hand, do not produce tobacco smoke

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addictive ) Unable to control the use of a habit-forming drug or to forego an unhealthy habit (such as video game playing or phone texting)

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