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First, glutamate-cysteine ligase (GCL) catalyzes the conjugation of cysteine and glutamate, which results in the formation of \(\gamma\)-glutamylcysteine

Additionally, a randomized clinical trial in non-symptomatic antiretroviral-nave patients showed that long-term exposure to PIs or NNRTIs is associated with disrupted glucose transport as well as disrupted lipid metabolism with increased insulin resistance (Shlay et al., 2007)

T., Khosrave, A

Updated 05/01/2024

This view radically changed with the discovery of apoptosis and its specific signaling pathways in the 1990s