Endometriotic implants secrete estradiol (E2) as well as prostaglandin E2 (PGE2), agents that attract macrophages (monocyte chemotactic protein 1[MCP-1]), neurotrophic peptides (nerve growth factor [NGF]), enzymes for tissue remodeling (matrix metalloproteinases [MMPs]) and tissue inhibitors of MMPs (TIMPs), and proangiogenic substances such as vascular endothelial growth factor (VEGF) and interleukin-8 (6)
"Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications." Curr Neuropharmacol
Data acquisition was using an Agilent 6546 Q-TOF instrument (ESI) with optimized parameters: gas temp 300 C, drying/sheath gas 8/11 L/min, capillary voltage 3500 V, and spray voltages 500/1000 V
View on PubMed [PubMed] The synergy of GHK-Cu and hyaluronic acid on collagen IV synthesis (2023) Research demonstrating synergistic collagen synthesis effects when GHK-Cu is combined with hyaluronic acid
Studies show significantly increased collagen, reticulin, and blood vessel formation[9]
Baseline was calculated from 4 naive animals to get the pre-op baseline for normal un-lesioned animals
